Thermodynamic calculations and statistical correlations for oligo-probes design
نویسندگان
چکیده
منابع مشابه
Oligo Design: a computer program for development of probes for oligonucleotide microarrays.
Oligonucleotide microarrays have demonstrated potential for the analysis of gene expression, genotyping, and mutational analysis. Our work focuses primarily on the detection and identification of bacteria based on known short sequences of DNA. Oligo Design, the software described here, automates several design aspects that enable the improved selection of oligonucleotides for use with microarra...
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Background: Secondary structure in the target is a property not usually considered in software applications for design of optimal custom oligonucleotide probes. It is frequently assumed that eliminating self-complementarity, or screening for secondary structure in the probe, is sufficient to avoid interference with hybridization by stable secondary structures in the probe binding site. Predicti...
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J is used for the development of algorithms for a variety of statistical calculations including means, medians and quartiles, frequency tabulations, variances and covariances, regression analysis, graphical presentation, analysis of variance, random number generation and simulation, nonparametric tests, and probability distributions. Apart from the first two sections the organization of the pap...
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ژورنال
عنوان ژورنال: Nucleic Acids Research
سال: 2003
ISSN: 1362-4962
DOI: 10.1093/nar/gkg476